Kalbfleisch and menggang yu university of michigan, university of michigan and indiana university we consider a class of doubly weighted rankbased estimating methods for the transformation or accelerated failure time model with. Semiparametric statistical theory, which is broadly speaking about the estimation of. Wellner springer verlag this book is a reprint of the book that appeared with johns hopkins university press in 1993. A semiparametric estimation of mean functionals with. Thus, our method, albeit semiparametric in spirit, is totally different from the existing semiparametric imputation methods of, for example, lipsitz et al. The estimation procedure fully utilizes the entire dataset to achieve increased efficiency, and the resulting coefficient estimators are rootn consistent and asymptotically normal. Pdf analysis of semiparametric regression models for. Pdf missing data imputation is an important issue in machine learning and data mining. Author links open overlay panel shigeyuki hamori a. A semiparametric mixture regression model for longitudinal data authors. Semiparametric regression analysis with missing response. Kriging regression imputation method to semiparametric.
We consider a class of doubly weighted rankbased estimating methods for the transformation or accelerated failure time model with missing data as arise, for. Missing data occur frequently in empirical studies in health and social sciences, often compromising our ability to make accurate inferences. The theory of missing data applied to semiparametric models is scattered throughout the literature with no thorough comprehensive treatment of the subject. C arroll this article considers bayesian analysis of matched casecontrol problems when one of the covariates is partially missing. The goal is to combine the simplicity of imputation.
The pretestposttest study is commonplace in numerous appli. Zhao 1994 and robins and rotnitzky 1992 are revisited for semiparametric regression models with missing data using the theory outlined in the monograph by bickel, klaassen, ritov, and wellner 1993. The description of the theory of estimation for semiparametric models is both rigorous and intuitive, relying on geometric ideas to reinforce the intuition and understanding of the theory. In statistics, a semiparametric model is a statistical model that has parametric and nonparametric components. The theory of missing data applied to semiparametric models is scattered. It starts with the study of semiparametric methods when there are no missing data. We consider the efficiency bound for the estimation of the parameters of semiparametric models defined solely by restrictions on the means of a vector of correlated outcomes, y, when the data on y are missing at random. Conditional moment models with data missing at random. This paper considers the problem of parameter estimation in a general class of semiparametric models when observations are subject to missingness at random. Pdf we consider the efficiency bound for the estimation of the parameters of. Further methodology and theory was developed by, e. This paper investigates a class of estimation problems of the semiparametric model with missing data.
Munich personal repec archive semiparametric spatial regression. This sensitivity is exacerbated when inverse probability weighting methods are used, which may overweight contaminated observations. Influence functions ifs are a core component of classic statistical theory. Semiparametric bayesian analysis of matched casecontrol. Missing data is a pervasive problem in data analyses, resulting in datasets that contain censored realizations of a target distribution. We may combine both ra and ipw estimators to form a doublyrobust. A parametric model is a model in which the indexing parameter. Missing data in populationbased studies can occur for several reasons, but the most common reasons in studies of older adults are nonparticipation and death. Pdf asymptotic theory for the semiparametric accelerated. In many cases, the treatment of missing data in an analysis is carried out in a casual. A major development in this area was the systematic development of information bounds for semiparametric regression models with covariates missing at random by robins, rotnitzky, and. In this paper, we consider a semiparametric regression model in the presence of missing covariates for nonparametric components under a bayesian framework. In this paper, we investigate general moment or conditional moment restriction models with missing data and establish an equivalence result whose main message is.
Identification, doubly robust estimation, and semiparametric. Semiparametric theory and missing data researchgate. Semiparametric theory and missing data anastasios tsiatis. These estimators can be used to correct for dependent. Joint modeling of missing data due to nonparticipation. We show that the semiparametric variance bound is the asymptotic variance of the optimal estimator in a class of inverse probability of censoring weighted estimators and that this bound is unchanged if the data are missing. While our largesample theory allows for a wide range of. An application to the 2014 cps asec jonathan rothbaum september 2, 2015 sehsd working paper 201515 abstract the current population survey annual social and economic supplement cps asec serves as the data source for official income, poverty, and inequality statistics in the united states. Semiparametric models allow at least part of the data generating process to be.
They can be viewed as an extension of generalized estimating equations estimators that allow for the data to be missing at random but not missing completely at random. Semiparametric bayesian analysis of matched casecontrol studies with missing exposure samiran s inha, bhramar m ukherjee,malayghosh, bani k. Semiparametric estimation of treatment effect in a pretestposttest study with missing data marie davidian, anastasios a. Missing data models a search on mathscinet in early may 2005 for semiparametric and missing data gave 15 hits. Kalbfleischand menggangyu university of michigan, university of michigan and indiana university we consider a class of doubly weighted rankbased estimating methods for the transformation or accelerated failure time model. Estimation in semiparametric models with missing data 789 from the imputed estimating function gn. Estimation in semiparametric models with missing data. Missing data often appear as a practical problem while applying classical models in the statistical analysis.
Calibration estimation of semiparametric copula models. An outcome is said to be missing not at random mnar if, conditional on the observed variables, the missing data mechanism still depends on. Efficient and adaptive estimation for semiparametric. In this book, tsiatis very carefully and didactically explains this theory. Semiparametric theory and missing data, by tsiatis, 2006, 404 pages. Penalized estimating functions and variable selection in. For many semiparametric problems, the estimation of regression coe cients without the task of variable selection does not pertain to the minimization of any objective function. In any longitudinal study, estimation of the mean of an outcome variable as a function of time is compromised due to missing data 1, 2, 3, 4. The supplementary material gives the semiparametric efficiency theory for estimation of natural direct effects with a known model for the mediator density. Abstract we develop inference tools in a semiparametric partially linear regression model with missing response data. Asymptotic theory for the semiparametric accelerated failure time model with missing data. This book combines much of what is known in regard to the theory of estimation for semiparametric models with missing data in an organized and comprehensive manner.
By adopting nonparametric components for the model, the estimation method can be made robust. Semiparametric theory and missing data springerlink. Asymptotic theory for the semiparametric accelerated. Important examples include weighted estimating equations for missing data robins et al. Semiparametric methods for missing data and causal inference abstract in this dissertation, we propose methodology to account for missing data as well as a strategy to account for outcome heterogeneity. We propose a multiple imputation estimator for parameter estimation in a quantile regression model when some covariates are missing at random. Efficient and adaptive estimation for semiparametric models 84 9780387984735. Analysis of semiparametric regression models for repeated outcomes in the presence of missing data james m. A semiparametric inference to regression analysis with.
Pdf semiparametric estimation with data missing not at. L1 theory was established by carbon, hallin and tran 1996. Missing data occurs frequently in empirical studies in health and social sciences, often compromising our ability to make accurate inferences. Pdf semiparametric efficiency in multivariate regression models. The main results are given in a more relevant format for. In statistics, missing data, or missing values, occur when no data value is stored for the variable in an observation. Estimation in semiparametric models with missing data springerlink. See kenward and carpenter 2007 for a comparison of the relative. Multiple imputation for missing values through conditional. Statistics in the pharmaceutical industry, 3rd edition. In order to overcome the robust defect of traditional complete data estimation method and regression imputation estimation technique, we propose a modified imputation estimation approach called krigingregression imputation. Strategies for bayesian modeling and sensitivity analysis m.
This paper investigates the estimation of semiparametric copula models with data missing at random. Missing data are a common occurrence and can have a significant effect on the conclusions that can be drawn from the data. Statistical science semiparametric estimation of treatment. Calibration estimation of semiparametric copula models with data missing at random. A semiparametric approach to account for complex designs. Semiparametric methods for missing data and causal. Parameter estimation in parametric regression models with missing coariatesv is considered under a survey sampling setup. Analysis of semiparametric regression models for repeated. Semiparametric theory and missing data springer series in statistics 9780387324487. Bridging a survey redesign using multiple imputation. Pdf semiparametric optimization for missing data imputation. Semiparametric theory and missing data by tsiatis, a. A semiparametric inference to regression analysis with missing coariatesv in survey data shu angy and jae kwang kim department of statistics, iowa state university abstract.
The results of this paper can be viewed as a step in lling the large gap be. Supplemental appendix to semiparametric theory for causal mediation analysis. Tsiatis, 2006 and the buckleyjames 1979 estimator for semiparametric 2. International conference on robust statistics 2016 1. Classical semiparametric inference with missing outcome data is not robust to contamination of the observed data and a single observation can have arbitrarily large influence on estimation of a parameter of interest. A semiparametric logistic regression model is assumed for the response probability and a nonparametric regression approach for missing data discussed in cheng 1994 is used in the estimator.
In the 90s, jamie robins and colleagues in harvard applied recently developed theory for semiparametric models to the problem of handling missing data. Springer verlag does the statistical community a great. Semiparametric regression models with missing data. A semiparametric mixture regression model for longitudinal. Theory and method analysis of semiparametric regression models for repeated outcomes in the presence of missing data.